Wednesday 27 July 2011

How does medicine actually work in our body?

Aww...sick again...have to take medicine again...


I'm pretty sure there are many people curious about how medicine has been deliver inside our body.
These are the question will be asked:

  • How to get the drug molecule to the target site?
  • How to get the drug to its target in one piece and avoid being broken down half way to the target site?
Now I will lead everyone to reveal these answer.
The scientist have make use of the liposomes or virosomes.


What are liposomes?
Liposome and phospholipid molecule




Liposomes basically are the microscopic vesicles particles composed of lipids.
It can filled with drugs and deliver to the target site safely.
The most common constituent of liposome is phospholipid that speontaneously form closed structures in aqueous because a phospholipid molecule has a hydrophilic head and a hydrophobic tail.
Hydrophilic means by "water-loving" while hydrophobic means by "water- fearing"
Since the head is hydrophilic, it will attracted to the water; however the tail is hydrophobic which will repeal from water molecules.


So, it will form a closed structures automatically.
This natural allignment creates two rows of tightly fitted phospholipid molecules which called as phospholipid bilayer.


Hydrophobic are intercalated within the membrane, on the other hand hydrophilic can be entrapped within the internal aqueous region.


action of liposome

Liposome filled with drug will reach the target site and the liposome will fused into the cell and release the drug into the cell.

What are the advantages of being using liposomes to deliver drugs?
  • Liposomes are non-toxic and biodegradeble.
  • Faster response.
  • Allow a smaller dosage to used.
  • To avoid drug to hydrolyse in stomach
  • Patient do not have to be unconscious
Now, you should know how drugs being deliver safely to the target site.  Have a nice day ^^

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